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Opioid antagonists, which include naloxone, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically considerable respiratory or circulatory depression secondary to acetaminophen and codeine overdose, administer an opioid antagonist.

The concomitant usage of acetaminophen and codeine phosphate tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) might bring about an increase in codeine plasma concentrations in addition to a lower in Lively metabolite morphine plasma concentration which could end in an analgesic efficacy reduction or symptoms of opioid withdrawal.

Acetaminophen and codeine phosphate tablets must be prescribed only by healthcare specialists who are professional about the usage of opioids and how to mitigate the affiliated pitfalls.

Aged sufferers (aged sixty five years or older) can have increased sensitivity to acetaminophen and codeine phosphate tablets. Normally, use warning when selecting a dosage for an elderly affected person, commonly starting on the very low close of your dosing variety, reflecting the increased frequency of lessened hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.

Other less regularly noticed adverse reactions expected from opioid analgesics, together with acetaminophen and codeine phosphate tablets:

In advance of using this merchandise, tell your health practitioner or pharmacist If you're allergic to acetaminophen or codeine; or to other opioid agony drugs (for instance morphine); or For those who have almost every other allergies.

Circumstances of OIH are actually described, both with brief-expression and for a longer period-phrase use of opioid analgesics. However the system of OIH is read more not really totally understood, many biochemical pathways have been implicated. Health-related literature implies a solid biologic plausibility in between opioid analgesics and OIH and allodynia.

While there are no conventional opioid tapering schedules well suited for all people, good clinical follow dictates tapering in small increments (e.

Advise both equally individuals and caregivers with regards to the dangers of respiratory depression and sedation when acetaminophen and codeine phosphate tablets are applied with benzodiazepines or other CNS depressants (such as Liquor and read more illicit medications). Recommend individuals never to travel or operate weighty equipment until eventually the effects of concomitant use on the benzodiazepine or other CNS depressant are actually determined.

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Expecting or planning to develop into pregnant. Utilization of acetaminophen and codeine phosphate tablets for an extended stretch of time during pregnancy might cause withdrawal signs and symptoms as part of your new child child which could be lifetime-threatening if not identified and treated.

A healthcare Experienced really should be consulted just before taking any drug, transforming any diet program or commencing or discontinuing any course of treatment method.

Warn sufferers to not travel or run harmful equipment unless They may be tolerant to the results of acetaminophen and codeine phosphate tablets and understand how they may respond towards the medication (see PRECAUTIONS, Data for People/Caregivers).